Senior Principal Scientist
Yann Abraham, Ph.D. is Senior Principal Scientist in the France Artificial Intelligence (AI)/Genomics group within Computational Sciences, Discovery Sciences (DS). In this position, Yann plays a key role in the analysis and integration of datasets generated through partnerships with institutions in the French biomedical research ecosystem, leveraging synergies with internal projects from the Janssen Therapeutic Areas and initiatives from the Data Science team within DS Computational Sciences. Yann joined Janssen in 2016 as a member of the Discovery Science Omics team where he was responsible for developing analytical solutions for single-cell proteomics platforms, including mass and flow cytometry, and for analyzing datasets generated in the context of multiple clinical trials. Yann has collaborated with numerous teams in the context of immuno-oncology, autoimmune disease, and vaccines, developing innovative solutions to visualize and interpret high-dimensional single-cell data. Prior to joining Janssen, Yann gained experience in the exploratory data analysis field working for Novartis Pharma AG in Basel, Switzerland, using transcriptomics (microarray and RNAseq) and proteomics data to identify and validate new targets. Yann also collaborated on the analysis of RNAi screens and helped pioneer the adoption of mass cytometry by analyzing the dose-dependent effects of glucocorticoid receptor agonists on macrophage polarization. Before his time at Novartis, Yann worked as a senior scientist for Cellzome AG, in Heidelberg, Germany. In that capacity, Yann contributed to the development of innovative chemical proteomics solutions using pan-specific compounds to enrich for specific target classes and estimate compound affinity and selectivity through mass spectrometry. Yann’s research interests include proteomics, graph-based analysis, and data visualization. He obtained his PhD in 2001 from the Université Paris XI in Orsay, France, working on the identification of proteins regulating centrosome duplication in human cells under the supervision of Michel Bornens in the Institut Curie in Paris, France.
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